Stem Cell and Gene Therapy for Cardiovascular Disease

ISBN-13: 9780128018880 / Angielski / Miękka / 2015 / 538 str.

Perin, Emerson C. Miller, Leslie W. Willerson, James T.

Opis

Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic.

• Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials
• Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis
• Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI
• Covers the prevailing opinions on how to harness the body's natural repair mechanisms
• Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals

Recenzje

"... accomplishes a thorough overview of the topic that is appropriate for the everyday cardiovascular practitioner, but it also can be used a stepping stone for anyone wishing to get deeply involved in the field. It is likely more comprehensive that any book currently on the market. Score: 80 - 3 Stars" --Doody's

Spis treści

1. Introduction and Overview of Stem Cells
2. Mechanistic Insights from Pathologic Perspective
3. Large Animal Models to Study Stem Cell Therapy
4. Evolution of understanding of the mechanisms of repair
5. Impact of Age on Stem Cell Function
6. Bone Marrow Mononuclear Cells
7. Chronic Limb Ischemia
8. Chronic/Refractory Angina
9. Acute Myocardial Infarction
A. European Experience
B. US Experience
10. Chronic Ischemic Heart Failure
11. Adipose Tissue
12. Overview of MSCs     
13. Allogeneic vs Autologous Source: Comparative Effects
14. Use of MSCs for AMI
15. Combined Cell Strategies
16. Heart Failure
17. C-Kit+ cells
18. Cardiospheres
19. Umbilical Cord, Placenta, Endometrium
20. Genetic Engineering of Fibroblasts to Cardiomyocytes
21. Transformation to inducible Pleuripotent Stem Cells
22. Transformation to MAPC's
23. Transcoronary and Endocardial
24. Retrograde and Epicardial
25. Epicardial Patch
26. Matrix Scaffolds
27. Matrix plus cells 
28. Biomaterial: Alginate
29. Organogenesis
30. Pre-clinical Identification of target genes
31. SERCA-2a gene for recovery of inotropic function
32. SDF-1 Gene for Heart Failure Non-Inotropic Mechanisms
33. Gene Therapy for Angiogenesis: Chronic Limb Ischemia 
34. Stem Cells Target Gene Transfected Stem Cells
35. CCTRN: Past, Present, and Vision for the Future
36. Signature of Responders-lessons from Bio-Repository
37. Adjunctive therapy with LVADs for Recovery
38. Trials in Non-Ischemic Heart Failure
39. Enhancing Stem Cell Homing for Tissue Repair
40. Stroke: Pre-Clinical and Clinical Trial Data